Ammonium Salts of 5-(3-Chromenyl)-5H-chromeno[2,3-b]pyridines

The ammonium salts of many drugs have significantly improved the solubility and, accordingly, bioavailability medicinal substances in human body. 5-(4-Hydroxy-2-oxo-2H-chromen-3-yl)-5H-chromeno[2,3-b]pyridines are potential NPY1R ligands, which attractive for antiobesity treatment. Ammonium 5H-chromeno[2,3-b]pyridines were previously unknown. In this communication, it was found that four-component reaction salicylaldehyde, 2-aminoprop-1-ene-1,1,3-tricarbonitrile, 4-Hydroxy-2H-chromen-2-one and amines results formation 5-(3-chromenyl)-5H-chromeno[2,3-b]pyridines. structure these unknown compounds confirmed by means 1H, 13C NMR IR spectroscopy, mass spectrometry elemental analysis.